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It has little intrinsic sympathomimetic activity, but has strong membrane stabilizing activity only at high blood concentrations, e. Both enantiomers of propranolol have a local anesthetic topical effect, which is normally mediated by blockade of voltage-gated sodium channels. Pharmacokinetics Propranolol is rapidly and completely absorbed, with peak plasma levels achieved about 1—3 hours after ingestion.

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  • Propranolol is classified as a non-cardioselective sympatholytic beta blocker that crosses the blood—brain barrier.
  • Both enantiomers of propranolol have a local anesthetic topical effect, which is normally mediated by blockade of voltage-gated sodium channels.

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